• The translation inhibitor rocaglamide targets a bimolecular cavity between eIF4A and polypurine RNA
  
  Shintaro Iwasaki, Wakana Iwasaki, Mari Takahashi, Ayako Sakamoto, Chiduru Watanabe, Yuichi Shichino, Stephen N. Floor, Koichi Fujiwara, Mari Mito, Kosuke Dodo, Mikiko Sodeoka, Hiroaki Imataka, Teruki Honma, Kaori Fukuzawa, Takuhiro Ito, Nicholas T. Ingolia
  Mol. Cell. 2019, 73, 738-748.
  
  理研プレスリリース (2018年12月28日)
  
• Detection of esterase activity by chromogenic and fluorogenic probe based on an O-nitrobenzoxadiazole (O-NBD) unit
  Kana Okada, Takao Yamaguchi, Kosuke Dodo, Mikiko Sodeoka, Satoshi Obika
  Bioorg. Med. Chem. 2019, 27, 1444-1448.
  
  
• Synthesis of all stereoisomers of RK460 and evaluation of their activity and selectivity as abscisic acid receptor antagonists
  Yu Mikame, Kazuko Yoshida, Daisuke Hashizume, Go Hirai, Kazuo Nagasawa, Hiroyuki Osada, Mikiko Sodeoka
  Chem. Eur. J. 2019, 25, 3496-3500.
  
  
• Control of site selectivity in trifluoromethylation of alkenes bearing a pendant indolyl group: Synthesis of CF3-containing tetrahedrocarbazoles
  Ryo Murakami, Daisuke Sekine, Yuma Aoki, Shintaro Kawamura, Mikiko Sodeoka
  Tetrahedron 2019, 75, 1327-1335.
  
  
• Tri-methylation of ATF7IP by G9a/GLP recruits the chromodomain protein MPP8
  Takeshi Tsusaka, Masaki Kikuchi, Tadahiro Shimazu, Takehiro Suzuki, Yoshihiro Sohtome, Mai Akakabe, Mikiko Sodeoka, Naoshi Dohmae, Takashi Umehara, Yoichi Shinkai
  Epigenetics & Chromatin 2018, 11:56.
• Reactivity and properties of bis(chlorodifluoroacetyl)peroxide generated in situ from chlorodifluoroacetic anhydride for chlorodifluoromethylation reactions
  Shintaro Kawamura, Cassandra J. Henderson, Yuma Aoki, Daisuke Sekine, Shū Kobayashi, Mikiko Sodeoka
  Chem. Commun. 2018, 54, 11276-11279.
  
  
• Metal-free alkene oxy- and amino-perfluoroalkylations via carbocation formation by using perfluoro acid anhydrides:
  unique reactivity between styrenes and perfluoro diacyl peroxides
  Elena Valverde, Shintaro Kawamura, Daisuke Sekine, Mikiko Sodeoka
  Chem. Sci. 2018, 9, 7115-7121.
  
  理研プレスリリース (2018年8月8日)
  
• Unveiling epidithiodiketopiperazine as a non-histone arginine methyltransferase inhibitor by chemical protein methylome analyses
  Yoshihiro Sohtome, Tadahiro Shimazu, Joaquin Barjau, Shinya Fujishiro, Mai Akakabe, Naoki Terayama, Kosuke Dodo, Akihiro Ito, Minoru Yoshida, Yoichi Shinkai, Mikiko Sodeoka
  Chem. Commun. 2018, 54, 9202-9205.
  
  理研プレスリリース (2018年8月6日)
  
• The alkyne-tag Raman imaging of coronatine, a plant pathogen virulence factor, in Commelina communis and its possible mode of action
  Minoru Ueda, Kengo Hayashi, Syusuke Egoshi, Yasuhiro Ishimaru, Yousuke Takaoka, Hiroyuki Yamakoshi, Kosuke Dodo, Mikiko Sodeoka
  Org. Biomol. Chem. 2018, 16, 3348-3352.
  
  
• Thienyl-Substituted α-Ketoamide: A Less Hydrophobic Reactive Group for Photo-Affinity Labeling
  Eisuke Ota, Kazuteru Usui, Kana Oonuma, Hiroyuki Koshino, Shigeru Nishiyama, Go Hirai, Mikiko Sodeoka
  ACS Chem. Biol. 2018, 13, 876-880.
  
  理研プレスリリース (2018年2月22日)
  
  
• Indolylmaleimide Derivative IM-17 Shows Cardioprotective Effects in Ischemia-Reperfusion Injury
  Kosuke Dodo, Tadashi Shimizu, Jun Sasamori, Kazuyuki Aihara, Naoki Terayama, Shuhei Nakao, Katsuya Iuchi, Masahiro Takahashi, Mikiko Sodeoka
  ACS Med. Chem. Lett. 2018, 9, 182-187.
  
  理研プレスリリース (2018年2月21日)
  
  
• Synthesis of CF₃-containing oxazolines via trifluoromethylation of allylamides with Togni reagent in the presence of alkali metal iodides
  Shintaro Kawamura, Daisuke Sekine, Mikiko Sodeoka
  J. Fluorine Chem. 2017, 203, 115-121.
  
  
  
• Hyperoxidation of ether-linked phospholipids accelerates neutrophil extracellular trap formation
  Satoshi Yotsumoto, Yuito Muroi, Tatsuya Chiba, Rio Ohmura, Maki Yoneyama, Megumi Magarisawa, Kosuke Dodo, Naoki Terayama, Mikiko Sodeoka, Ryohei Aoyagi, Makoto Arita, Satoko Arakawa, Shigeomi Shimizu, Masato Tanaka
  Scientific Reports 2017, 7, Article number: 16026.
  
• N-Heterocycle-Forming Amino/Carboperfluoroalkylations of Aminoalkenes by Using Perfluoro Acid Anhydrides: Mechanistic Studies and Applications Directed Toward Perfluoroalkylated Compound Libraries
  Shintaro Kawamura, Kento Dosei, Elena Valverde, Kiminori Ushida, Mikiko Sodeoka
  J. Org. Chem. 2017, 82, 12539-12553.
  
  理研プレスリリース (2017年11月9日)
  
  
• Specific fluorescence labeling of target proteins by using a ligand-4-azidophthalimide conjugate
  Kosuke Chiba, Miwako Asanuma, Minoru Ishikawa, Yuichi Hashimoto, Kosuke Dodo, Mikiko Sodeoka, Takao Yamaguchi
  Chem. Commun. 2017, 53, 8751-8754.
  
  
• Crystal structural characterization reveals novel oligomeric interactions of human voltage-dependent anion channel 1
  Toshiaki Hosaka, Masateru Okazaki, Tomomi Kimura-Someya, Yoshiko Ishizuka-Katsura, Kaori Ito, Shigeyuki Yokoyama, Kosuke Dodo, Mikiko Sodeoka, Mikako Shirouzu
  Protein Sci. 2017, 26, 1749-1758.
  
• Catalytic Enantioselective [3 + 2] Cycloaddition of α-Keto Ester Enolates and Nitrile Oxides
  Samuel L. Bartlett, Yoshihiro Sohtome, Daisuke Hashizume, Peter S. White, Miki Sawamura, Jeffrey S. Johnson, Mikiko Sodeoka 
  J. Am. Chem. Soc. 2017, 139, 8661-8666.
  
  
  
• Noncanonical Function of a Small-Molecular Virulence Factor Coronatine against Plant Immunity: An In Vivo Raman Imaging Approach
  Minoru Ueda, Syusuke Egoshi, Kosuke Dodo, Yasuhiro Ishimaru, Hiroyuki Yamakoshi, Takeshi Nakano, Yousuke Takaoka, Shinya Tsukiji, Mikiko Sodeoka
  ACS Cent. Sci. 2017, 3, 462–472.
  
  東北大学プレスリリース (2017年5月17日)
  
  
• Naked d-orbital in a centrochiral Ni(II) complex as a catalyst for asymmetric [3+2] cycloaddition
  Yoshihiro Sohtome, Genta Nakamura, Atsuya Muranaka, Daisuke Hashizume, Sylvain Lectard, Teruhisa Tsuchimoto, Masanobu Uchiyama, Mikiko Sodeoka
  Nat. Commun. 2017, 8, 14875.
  
  理研プレスリリース (2017年4月6日)
  
• Reversibility of 3-Phenyl-2-oxindole Dimer Formation: Application to Construct Compounds with Two Distinct Vicinal All-Carbon Quaternary Centers
  Yoshihiro Sohtome, Masumi Sugawara, Daisuke Hashizume, Daiki Hojo, Miki Sawamura, Atsuya Muranaka, Masanobu Uchiyama, Mikiko Sodeoka
  Heterocycles 2017, 95, 1030-1040.
  
  
• Synthesis of the Right-Side Structure of Type B Physalins
  Masaki Morita, Shuntaro Kojima, Megumi Ohkubo, Hiroyuki Koshino, Daisuke Hashizume, Go Hirai, Keiji Maruoka, Mikiko Sodeoka
  Isr. J. Chem. 2017, 57, 309-318.
  
  
• Development of Dual-specificity Protein Phosphatases Inhibitors based on Focused Library Approach: Modification of a Core Structure and Unique Inhibition Mechanism
  Go Hirai, Miwako Asanuma, Ayako Tsuchiya, Mikiko Sodeoka
  J. Synth. Org. Chem. Jpn. 2016, 74, 532-540.
• A new carbamidemethyl-linked lanthanoid chelating tag for PCS NMR spectroscopy of proteins in living HeLa cells
  Yuya Hikone, Go Hirai, Masaki Mishima, Kohsuke Inomata, Teppei Ikeya, Souichiro Arai, Masahiro Shirakawa, Mikiko Sodeoka, Yutaka Ito
  J. Biomol. NMR 2016, 66, 99-110.
• Comparative Characterization of the Leaf Tissue of Physalis alkekengi and Physalis peruviana Using RNA-seq and Metabolite Profiling
  Atsushi Fukushima, Michimi Nakamura, Hideyuki Suzuki, Mami Yamazaki, Eva Knoch, Tetsuya Mori, Naoyuki Umemoto, Masaki Morita, Go Hirai, Mikiko Sodeoka, Kazuki Saito
  Front. Plant Sci. 2016, 7, 1883.
• Solvent-dependent copper-catalyzed synthesis of pyrazoles under aerobic conditions
  Florian Pünner, Yoshihiro Sohtome, Mikiko Sodeoka
  Chem. Commun. 2016, 52, 14093-14096.
  
  Back cover
  Chem. Commun. 2016, 52, 14174.

• Alkyne-tag SERS screening and identification of small-molecule-binding sites in protein
  Jun Ando, Miwako Asanuma, Kosuke Dodo, Hiroyuki Yamakoshi, Satoshi Kawata, Katsumasa Fujita, Mikiko Sodeoka
  J. Am. Chem. Soc. 2016, 138, 13901-13910.

• Structure-activity relationship study of 3-amino-2-indolyllactam derivatives: Development of inhibitors of oxidative stress-induced necrosis
  Kosuke Dodo, Kenji Hayamizu, Tadashi Shimizu, Mikiko Sodeoka
  Chem. Pharm. Bull. 2016, 64, 886-898.

• Perfluoroalkylation of Unactivated Alkenes with Acid Anhydrides as the Perfluoroalkyl Source
  Shintaro Kawamura, Mikiko Sodeoka
  Angew. Chem. Int. Ed. 2016, 55, 8740-8743.

• Photochemical and Additive-free Coupling Reaction of α-Cumyl α-Ketoesters via Intermolecular C-H Bond Activation
  Eisuke Ota, Yu Mikame, Go Hirai, Shigeru Nishiyama, Mikiko Sodeoka
  Synlett 2016, 27, 1128-1132.

• Identification of Nitrogen Signaling Factors that regulate adaptive nitrogen metabolism in fission yeast
  Xiaoying Sun, Go Hirai, Masashi Ueki, Hiroshi Hirota, Qianqian Wang, Yayoi Hongo, Takemichi Nakamura, Yuki Hitora, Hidekazu Takahashi, Mikiko Sodeoka, Hiroyuki Osada, Makiko Hamamoto, Minoru Yoshida, Yoko Yashiroda
  Scientific Report 2016, 6, 20856.
• Dual function of coronatine as a bacterial virulence factor against plants: possible COI1–JAZindependent role
  Syusuke Egoshi, Yousuke Takaoka, Hiroaki Saito, Yuuki Nukadzuka, Kengo Hayashi, Yasuhiro Ishimaru, Hiroyuki Yamakoshi, Kosuke Dodo, Mikiko Sodeoka, Minoru Ueda
  RSC Adv. 2016, 6, 19404–19412.

• A Platinum-Catalyzed Friedel-Crafts-Type C-H Coupling-Allylic Amination Cascade to Synthesize 3,4-Fused Tricyclic Indoles
  Yuta Suzuki, Yuito Tanaka, Shun-ichi Nakano, Kosuke Dodo, Natsumi Yada, Ken-ichi Shinohara, Kazuko Kita, Atsushi Kaneda, Mikiko Sodeoka, Yasumasa Hamada, Tetsuhiro Nemoto
  Chem. Eur. J. 2016, 22, 4418-4421.

  

• Dual-Polarization Raman Spectral Imaging to Extract Overlapping Molecular Fingerprints of Living Cells
  Liang-da Chiu, Almar F. Palonpon, Nicholas I. Smith, Satoshi Kawata, Mikiko Sodeoka, Katsumasa Fujita
  J. Biophotonics 2015, 8, 546-554.

• VDAC3 gating is activated by suppression of disulfide-bond formation between the N-terminal region and the bottom of the pore
  Masateru Okazaki , Katsue Kurabayashi, Miwako Asanuma, Yohei Saito, Kosuke Dodo, Mikiko Sodeoka
  Biochim. Biophys. Acta (Biomembranes) 2015, 1848, 3188-3196.

• Photo-induced formation of cyclopropanols from α-ketoamides via γ-C-H bond activation
  Eisuke Ota, Yu Mikame, Go Hirai, Hiroyuki Koshino, Shigeru Nishiyama, Mikiko Sodeoka
  Tetrahedron Lett. 2015, 56, 5991-5994.

• Unique features of chiral palladium enolates derived from β-ketoamide: Structure and catalytic asymmetric Michael and fluorination reactions
  Kenji Hayamizu, Naoki Terayama, Daisuke Hashizume, Kosuke Dodo, Mikiko Sodeoka
  Tetrahedron 2015, 71, 6594-6601.

• Novel Raman-tagged sphingomyelin that closely mimics original raft-forming behavior
  Jin Cui, Shigeru Matsuoka, Masanao Kinoshita, Nobuaki Matsumori, Fuminori Sato, Michio Murata, Jun Ando, Hiroyuki Yamakoshi, Kosuke Dodo, Mikiko Sodeoka
  Bioorg. Med. Chem. 2015, 23, 2989-2994.

• Mechanistic Study on A unique SN2’-type reaction of allylic alcohols with organolithium reagent accelerated by a proximal trifluoromethyl group
  Hiromichi Egami, Yoshihiko Usui, Shintaro Kawamura, Ryo Shimizu, Sayoko Nagashima, Mikiko Sodeoka
  J. Fluorine Chem. 2015, 179, 121-128.

• Reactions of Carbonyl Compounds with Phosphorus Ylide Generated from Tribromofluoromethane and Tris(dimethylamino)phosphine
  Go Hirai, Eri Nishizawa, Daiki Kakumoto, Masaki Morita, Mitsuaki Okada, Daisuke Hashizume, Sayoko Nagashima, Mikiko Sodeoka
  Chem. Lett. 2015, 44, 1389-1391.

• Product Control in Alkene Trifluoromethylation: Hydro-trifluoromethylation, Vinylic Trifluoromethylation, and Iodo-trifluoromethylation Using Togni Reagent
  Hiromichi Egami, Yoshihiko Usui, Shintaro Kawamura, Sayoko Nagashima, Mikiko Sodeoka
  Chem. Asian J. 2015, 10, 2190-2199.

• Sphingomyelin distribution in lipid rafts of artificial monolayer membranes visualized by Raman microscopy
  Jun Ando, Masanao Kinoshita, Jin Cui, Hiroyuki Yamakoshi, Kosuke Dodo, Katsumasa Fujita, Michio Murata, Mikiko Sodeoka
  Proc. Nat. Acad. Sci. 2015, 112, 4558-4563.
  
  JST プレスリリース (2015年3月31日)

• Aminotrifluoromethylation of Olefins via Cyclic Amine Formation: Its Mechanistic Study and Application to Synthesis of Trifluoromethylated Pyrrolidines
  Shintaro Kawamura, Hiromichi Egami, Mikiko Sodeoka
  J. Am. Chem. Soc. 2015, 137, 4865-4873.

• A sensitive and specific Raman probe based on bisarylbutadiyne for live cell imaging of mitochondria
  Hiroyuki Yamakoshi, Almar Palonpon, Kosuke Dodo, Jun Ando, Satoshi Kawata, Katsumasa Fujita, Mikiko Sodeoka
  Bioorg. Med. Chem. Lett. 2015, 25, 664-667.

• Saccharothriolides A-C, Novel Phenyl-substituted 10-Membered Macrolides from a Rare Actinomycete Saccharothrix sp.
  Shan Lu, Shinichi Nishimura, Go Hirai, Masashi Ito, Teppei Kawahara, Miho Izumikawa, Mikiko Sodeoka, Kazuo Shin-ya, Toshio Tsuchida, Hideaki Kakeya
  Chem. Commun. 2015, 51, 8074-8077.

• Selenium-Based S-Adenosylmethionine Analog Reveals the Mammalian Seven-Beta-Strand Methyltransferase METTL10 to Be an EF1A1 Lysine Methyltransferase
  Tadahiro Shimazu, Joaquin Barjau, Yoshihiro Sohtome, Mikiko Sodeoka, Yoichi Shinkai
  Plos One 2014, 9, e105394.

• Dual Catalysis with Copper and Rhenium for Trifluoromethylation of Propargylic Alcohols: Efficient Synthesis of α-Trifluoromethylated Enones
  Hiromichi Egami, Takafumi Ide, Masashi Fujita, Toshifumi Tojo, Yoshitaka Hamashima, Mikiko Sodeoka
  Chem. Eur. J. 2014, 20, 12061-12065.

• A “Catch-and-Release” Protocol for Alkyne-Tagged Molecules Based on a Resin-Bound Cobalt Complex for Peptide Enrichment in Aqueous Media
  Ayako Miyazaki, Miwako Asanuma, Kosuke Dodo, Hiromichi Egami, Mikiko Sodeoka
  Chem. Eur. J. 2014, 20, 8116-8128.

• Oxy-trifluoromethylation of alkenes and its application to the synthesis of β-trifluoromethylstyrene derivatives
  Hiromichi Egami, Ryo Shimizu, Yoshihiko Usui, Mikiko Sodeoka
  J. Fluorine Chem. 2014, 167, 172-178.

• RE12 derivatives displaying Vaccinia H1-related phosphatase (VHR) inhibition in the presence of detergent and their anti-proliferative activity against HeLa cells
  Frederic Thuaud, Shuntaro Kojima, Go Hirai, Kana Oonuma, Ayako Tsuchiya, Takako Uchida, Teruhisa Tsuchimoto, Mikiko Sodeoka
  Bioorg. Med. Chem. 2014, 22, 2771-2782.

• Turn-ON fluorescent affinity labeling using a small bifunctional o-nitrobenzoxadiazole unit
  Takao Yamaguchi, Miwako Asanuma, Shuichi Nakanishi, Yohei Saito, Masateru Okazaki, Kosuke Dodo, Mikiko Sodeoka
  Chem. Sci. 2014, 5, 1021-1029.

            JSTプレスリリース (2013年12月16日)

• Simultaneous imaging of protonated and deprotonated carbonylcyanide p-trifluoromethoxyphenylhydrazone in live cells by Raman microscopy
  Hiroyuki Yamakoshi, Almar F. Palonpon, Kosuke Dodo, Jun Ando, Satoshi Kawata, Katsumasa Fujita, Mikiko Sodeoka
  Chem. Commun. 2014, 50, 1341-1343.

• Molecular imaging of live cells by Raman microscopy
  Almar F. Palonpon, Mikiko Sodeoka, Katsumasa Fujita
  Curr. Opin. Chem. Biol. 2013, 17, 708-715.
• Iron-catalyzed trifluoromethylation with concomitant C-C bond formaiton via 1,2-migration of an aryl group
  Hiromichi Egami, Ryo Shimizu, Yoshihiko Usui, Mikiko Sodeoka
  Chem. Commun. 2013, 49, 7346-7348.

• Unexpected Diels-Alder/Carbonyl-ene Cascade toward the Biomimetic Synthesis of Chloropupukeananin
  Takahiro Suzuki, Yuria Miyajima, Kaname Suzuki, Kanako Iwakiri, Masaki Koshimizu, Go Hirai, Mikiko Sodeoka, Susumu Kobayashi
  Org. Lett. 2013, 15, 1748-1751.

• Development of bis-unsaturated ester aldehydes as amino-glue probes: sequential double azaelectrocyclization as a promising strategy for bioconjugation
  Katsunori Tanaka, Yuka Nakamoto, Eric R. O. Siwu, Ambara R. Pradipta, Koji Morimoto, Takeshi Fujiwara, Suguru Yoshida, Takamitsu Hosoya, Yuki Tamura, Go Hirai, Mikiko Sodeoka, Koichi Fukase
  Org. Biomol. Chem. 2013, 11, 7326-7333.

• Trifluoromethylation Reactions for the Synthesis of β-Trifluoromethylamines
  Hiromichi Egami, Shintaro Kawamura, Ayako Miyazaki, Mikiko Sodeoka
  Angew. Chem. Int. Ed. 2013, 52, 7841-7844.

• Contribution of Cage-Shaped Structure of Physalins to Their Mode of Action in Inhibition of NF-kB Action
  Masaaki Ozawa, Masaki Morita, Go Hirai, Satoru Tamura, Masao Kawai, Ayako Tsuchiya, Kana Oonuma, Keiji Maruoka, Mikiko Sodeoka
  ACS Med. Chem. Lett. 2013, 4, 730-735.

• Synthesis and evaluation of 2, 3-dinorprostaglandins: dinor-PGD1 and 13-epi-dinor-PGD1 are peroxisome proliferator-activated receptor α/γ dual agonists
  Ayato Sato, Kosuke Dodo, Makoto Makishima, Yuichi Hashimoto, Mikiko Sodeoka
  Bioorg. Med. Chem. Lett. 2013, 23, 3013-3017.

• Concise synthesis of oxindole derivatives bearing a 3-trifluoroethyl group: Copper-catalyzed trifluoromethylation of acryloanilide
  Hiromichi Egami, Ryo Shimizu, Mikiko Sodeoka
  J. Fluorine Chem. 2013, 152, 51-55.

• CDC25A-inhibitory RE Derivatives Bind to Pocket Adjacent to the Catalytic Site
  Ayako Tsuchiya, Miwako Asanuma, Go Hirai, Kana Oonuma, Muhammad Muddassar, Eri Nishizawa, Yusuke Koyama, Yuko Otani, Kam Y. J. Zhang, Mikiko Sodeoka
  Mol. BioSyst. 2013, 9, 1026-1034.

• Alkene Trifluoromethylation Coupled with C-C Bond Formation: Construction of Trifluoromethylated Carbocycles and Heterocycles
  Hiromichi Egami, Ryo Shimizu, Shintaro Kawamura, Mikiko Sodeoka
  Angew. Chem. Int. Ed. 2013, 52, 4000-4003.